Successful study aimed at confirming the ability of XV LVAS software to detect lung disease in involved military veterans
LOS ANGELES, September 1, 2022 /PRNewswire/ — 4DMedical, the leading developer of functional imaging software for respiratory diseases, announced the successful completion of a study by Vanderbilt University Veterans Medical Center after deployment, referred by the Nashville VA. The pilot study was undetectable by CT scanning and PFT testing and showed that XV LVAS® analysis software successfully and non-invasively detected constrictive bronchiolitis in military veterans. assistant professor Bradley W. Richmond, MD Ph.D., Department of Allergy, Pulmonary and Critical Care Medicine is the principal investigator. The published results are coming.
“We see a lot” Iraq and Afghanistan veterans with lung biopsies showing significant damage, but traditional non-invasive testing appears normal,” said Dr. Richmond. “We are hopeful that 4DMedical’s technology can help us diagnose lung disease in these veterans without the need for a surgical lung biopsy. is. If our efforts are successful, we expect that this technology could also be used to detect other lung diseases earlier than traditional testing, so that patients can start treatment earlier.”
Post Deployment Respiratory Syndrome (PDRS) is the term used to describe symptoms in U.S. military personnel and veterans who were exposed to toxins, primarily fire pits, during their deployment. Constrictive bronchiolitis is a rare lung disease diagnosed in conflict veterans in Iraq and Afghanistan1. While these veterans have findings of constrictive bronchiolitis on lung biopsies, noninvasive tests such as PFTs, chest X-rays, and CT scans are often common. XV LVAS is an image analysis algorithm that uses standard fluoroscopy to quantify ventilation with sufficient fidelity to identify regional differences.
on August 10, 2022chair Joe Biden signed into law a broad extension of health benefits to millions of veterans exposed to toxic burns. The estimated 3.5 million veterans who have been exposed to harmful toxins during their deployment to operations since 2001 will now benefit from an additional $280 billion care obligation in ten years. Importantly, the new law also relieves veterans of the burden of proof that an illness is linked to toxic exposure, listing CB as a suspected condition. Included in this legislation is the VHA’s requirement to provide toxic exposure screening for each of the 9 million veterans participating in VHA.
The researchers hypothesize the XV technology®, when applied to standard fluoroscopic images, is more sensitive in diagnosing constrictive bronchiolitis than PFTs, chest radiographs, and CT scans in veterans. Specific metrics evaluated with the 4DMedical software included measurements of ventilation heterogeneity demonstrating a shift in the proportion of ventilation to different regions in the lungs. Endpoints were compared during inhalation and a complete exhalation with residual volume of total lung capacity.
“We are honored that Dr. Richmond and his colleagues at Vanderbilt Medical Center and the VA are testing the efficacy of XV LVAS. In addition, we are pleased that the Vanderbilt study confirms our ability to detect diseases in military veterans that can currently only be diagnosed through an invasive and high-risk biopsy procedure,” said CEO and Founder Andreas Fouras. “With the passage of the PACT Act, it is imperative that clinicians be able to safely, quickly and effectively screen large numbers of veterans efficiently and economically. XV LVAS clearly has the potential to differentiate between healthy and diseased lungs associated with keep up with posting abroad.”
4DMedical (formerly known as 4Dx) is a global medical technology company transforming respiratory diagnostics for all lung diseases, including Lung COVID, Asthma, Chronic Obstructive Pulmonary Disease (COPD), Cystic Fibrosis and Cancer. XV LVAS analysis software detects constrictive bronchiolitis and is less invasive and less expensive than current, traditional methods used to scan military veterans. 4DMedical technology gives clinicians greater insight into lung function and the impact of diseases and treatment interventions.
More information at: https://4dmedical.com/
King MS, Eisenberg R, Newman JH, Tolle JJ, Harrell FE Jr, Nian H, Ninan M, Lambright ES, Sheller JR, Johnson JE, Miller RF. Constrictive bronchiolitis in soldiers returning from Iraq and Afghanistan. N Engl J Med. 2011;365:222–30
Media contact: Lizzy GuytonLizzy@southandhill.com
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